EstroVantage EM by Bioclinic Naturals at TheMinusShop.com. Free shipping.

EstroVantage EM by Bioclinic Naturals at TheMinusShop.com. Free shipping.

Primary Use: An increased ratio of 2-OHE:16a-OHE1, two estrogen metabolites, is associated with a reduced risk of invasive breast cancer risk in premenopausal women.

Several natural products found in EstroVantage EM support this concept including, DIM and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events. Other compounds in EstroVantage EM, including calcium-d-glucarate, inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption. It is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.
Benefits: IGF-1 has a known pathogenic role in cancer, increasing growth of existing cancer cells. Lycopene supplementation decrease IGF-1 by 25%. In a 34 patient randomized controlled trial foods enriched with bioactive compounds, including rosemary extract (Rosemarinus officinalis), were found to be a promising adjuvant therapy in advanced breast cancer patients Green tea polyphenols inhibit the proliferation of breast cancer cells in vivo and in vitro. Silymarin can down-regulate gene products involved in the proliferation of tumor cells (cyclin D1, EGFR, COX-2, TGF-beta, IGF-IR), invasion (MMP-9), angiogenesis (VEGF) and metastasis (adhesion molecules). Curcumin inhibits human breast cancer cell growth by mediating certain signaling cascades including the modulation of the NF-kB signaling pathway. Sulforaphane can inhibit the expression of estrogen receptor alpha (ERalpha) protein in MCF-7 cells, inhibiting proliferation and down-regulating hormone receptor expression. Standardized extracts.

Serving Size: 3 capsules.
Amount Per Serving: Calcium D-Glucarate ... 225mg (d-glucaric acid calcium salt) Indole-3-Carbinol ... 225mg (3-hydroxymethylindole) Green Tea Extract ... 150mg (Camellia sinensis)(leaf) (80% catchins, 45% EGCg less than 1% caffeine) Tomato Extract ... 150mg (Lycopersicon esculentum)(fruit) (5% lycopene) Broccoli Powder ... 83mg (Brassica oleracea var. italica)(aerial) (0.36% sulforaphane) Turmeric Extract ... 75mg (Curcuma longa)(root) (95% curcuminoids) Milk Thistle Extract ... 75mg (Silybum marianum)(seed) (60% silymarin) DIM ... 75mg (3,3'-diindolylmethane) Rosemary Extract ... 38mg (Rosmarinus officinalis)(leaf).

This product has not been evaluated by the FDA. It is not intended to diagnose, treat, cure or prevent any disease.